Paper

Insufficient Data, Misleading Recommendations Led To Significant Early Heterogeneity In Global COVID-19 Patient Management, According To Recent BMJ Study

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While there was extensive use of drug repurposing throughout the first 10 months of the COVID-19 pandemic, there was substantial heterogeneity over the types of drugs used for treatment purposes globally. Some drugs, including hydroxychloroquine, saw sharp declines in use, while adjunctive therapies grew into a more relied upon method for patient management. In a … Read more

Second high-impact paper published based on the results of OHDSI’s LEGEND study!

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According to a recent OHDSI paper, chlorthalidone, the guideline-recommended diuretic for lowering blood pressure, causes more serious side effects than hydrochlorothiazide, a similarly effective diuretic. The findings, published in JAMA Internal Medicine, contrast with current treatment guidelines recommending chlorthalidone over hydrochlorothiazide. The results were generated by the Large-Scale Evidence Generation and Evaluation in a Network … Read more

EHDEN knee replacement study results published in Lancet Rheumatology, truly elevating observational data.

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Oxford, 7th November 2019: The IMI European Health Data & Evidence Network (EHDEN) project is pleased to announce the publication of the results of its first ‘study-a-thon’ in Lancet Rheumatology the effectiveness and safety associated with unicompartmental versus total knee replacement, a milestone after its first year.1 The choice of which type of knee replacement … Read more