Work packages

WP1: Evidence Workflow Development

WP2: Outcome Driven Healthcare

WP3: Personalised Medicine

WP4: Technical Implementation

WP Leads: Daniel Prieto-Alhambra (University of Oxford) & Michael Arend (Bayer)

WP Leads: Jacoline Bouvy (NICE) & Farhan Hameed (Pfizer)

WP Leads: Peter Rijnbeek (Erasmus Medical Centre) & Mark Kruger (Sanofi)

WP Leads: Kees van Bochove (The Hyve) & Michel van Speybroeck (Janssen)

Development of use cases to explore topic-specific aspects of governance and quality assessment, provide input for collaboration framework and formulate requirements for the development of analytical tools and interactive dashboards to share study results.

WP2 will enable the transition towards outcomes-driven healthcare systems in Europe. This can only be achieved if the EHDEN framework can be used in the context of regulatory approval, health technology assessment (HTA), and for payer purposes. As the EHDEN project is using the OMOP-CDM to build a federated network of data sources standardised to a common data model, WP2 will test whether the OMOP-CDM can be used for said regulatory, HTA and payer activities.

WP3 aims to develop a standardized process to enable personalized decision-making. This includes well-calibrated patient-centredpredictive models and risk-effect estimation methods that can be utilized for multiple outcomes of interest to patients and can be applied to observational healthcare data from any patient subpopulation of interest available in the OMOP-CDM.

WP4 is responsible for the technical coordination and development of the EHDEN framework and all its tools and services. This WP collects all requirements from the other work packages and translates these to specific technical implementations.

WP5: Data Workflow Implementation & Service Development

WP6: Outreach and Sustainability

WP7: Project management and Dissemination

WP Leads: Peter Rijnbeek (EMC), Matt Wiener (Celgene) & Töresin Karakoyun (Bayer)
WP Leads: Carlos Diaz (Synapse) & Johann Proeve (Bayer)
WP Leads: Carlos Diaz (Synapse) & Nigel  Hughes (Janssen)
WP5 will implement the full Data Workflow and to deploy all the services developed in EHDEN. This includes the implementation of the validation framework, the implementation of the SME onboarding, and the data source onboarding. This work will be done in close collaboration with WP4 and WP6. Moreover, WP5 will be involved in the actual study execution in the data network driven by WP1-3.
WP6 will be devoted to the development of exploitation strategies that work for all stakeholders and ensure long-term sustainability of EHDEN and its components. The definition of value propositions is at the core of WP6. Exploitation scenarios will start to be developed from the early stages of the project, incorporating the future users in the identification of their needs. Moreover, WP6 will lead the development of an EHDEN community encompassing all key stakeholders, and based on the consortium’s wide network.
WP7 will provide scientific guidance and professional project management for solving trade-offs between scope, time, quality and cost to ensure adequate progress and successful completion of the project. Moreover, it will provide guidance for and monitoring of the dissemination of the project results.