Aridhia’s mission is to enable large scale data science programs for biomedical research and innovation. Our platform provisions relevant datasets, data management pipelines and analysis methods to scale biomedical research programs within healthcare systems. The company has worked over the past 10 years to develop, release and support a Digital Research Environment (DRE) - a hybrid PaaS/SaaS platform to address many of the common challenges associated with achieving biomedical data science scale and sustainability. Our proposed solution helps to deliver those outcomes and aligns to best practice principles from the Global Alliance for Genomics and Health (GA4GH) Framework for Responsible Sharing of Genomic and Health Related Data, the FAIR guiding principles for scientific data management and the extensive use of open source software for reproducible analytics